New test could calculate your risk of dying from coronavirus Brighton News

ARTIFICIAL intelligence that searches for increased inflammation of blood vessels could calculate the risk of dying from coronavirus and its variants, research shows.

The new technology could be used to tailor treatment and give people the best chance of recovery.

That’s according to new research funded by the British Heart Foundation (BHF).

Severe cases of Covid-19 have been linked to a cytokine storm, where the virus spike protein overloads the immune system and produces a wave of damaging molecules called cytokines.

Using routine chest CT scans, researchers at the University of Oxford developed a Covid-19 signature using machine learning.

It detects biological red flags in the fat surrounding blood vessels in the chest to measure the level of cytokine-induced inflammation in people infected with the virus.

New test could calculate your risk of dying from coronavirus

New test could calculate your risk of dying from coronavirus

Charalambos Antoniades, Professor of Cardiovascular Medicine and Principal Investigator at BHF in the Radcliffe Department of Medicine at the University of Oxford, said: “We have built an incredibly adaptable AI platform that tracks vascular disease by decoding information images of blood vessels obtained on admission to hospital and integrating it with a large bioresource of RNA from human tissue biopsies.

“By simply adding an extra step to the routine care of people admitted to hospital with Covid-19 who already have a CT scan, we can now detect patients at high risk for life-threatening complications and could potentially adapt their treatment to help for a long time.” -term of recovery.

“But the benefits don’t end there.

“We know that this exaggerated immune response to the virus can also cause abnormal blood clotting, so we are developing this AI platform to specifically identify Covid-19 patients who are most at risk for a future heart attack or a cerebral vascular accident.

“We can also easily rotate our platform to develop a new scan ‘signature’ to better understand future viruses and diseases that will take hold of our population.

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Scientists applied the Covid-19 signature to chest CT scans of 435 people admitted to hospitals in Oxford, Leicester and Bath, and compared the degree of inflammation and risk of death in people with and without Covid-19.

They found that for patients admitted to hospital, the level of cytokine-induced inflammation in the blood vessels was much higher in those with Covid-19, and even higher in patients infected with the Kent variant. , or alpha.

Researchers found that people with high levels of vascular inflammation were up to eight times more likely to die in hospital and were the most likely to respond well to the anti-inflammatory drug Dexamethasone.

New test could calculate your risk of dying from coronavirus

New test could calculate your risk of dying from coronavirus

Covid-19 patients with elevated vascular inflammation treated with dexamethasone had a six-fold reduction in the risk of death compared to Covid-19 patients who did not receive the drug.

Researchers say that by using this tool to get an inflammation score, patients with significant inflammation in their blood vessels, and therefore at increased risk of death, could potentially be given anti-inflammatory drugs to reduce their risk and help. their long lifespan. recovery over time.

Clinical trials are now examining the effectiveness of this approach presented at the British Cardiovascular Society conference.

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This notice was published: 2021-06-08 15:24:45

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